Some weapons fire in straight line, such as the shotgun, but many such as grenades and bazooka shells follow curved trajectories (from gravity and wind) and can attack distant targets behind obstacles. Reloaded features a wide variety of weapons, some based on real weapons and others imaginary. Once the player uses a weapon, the 'escape' timer starts, giving up to five seconds to move the worm to a safe position before the turn ends. The player has a preset amount of time to move or attack with the worm before the turn ends (5 to 90 seconds). Movement is primarily accomplished through crawling and jumping, but items such as the jet pack and ninja rope can enable much faster travel and access to more terrain. When 'Artillery' mode is not enabled, worms can move across the landscape.

There is also a 'race' mode where the objective is to reach the end point in less time.

In the standard gameplay, the objective is to eliminate all enemy worms and be the last team standing. Worms Reloaded is a turn based artillery game, in which players command a team of up to four worms during each turn the player controls a single one of his or her worms.

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